Linus Owen is a young professor of conspiracy theory at a small college just outside San Francisco. His marriage is foundering and his wife, Claudia, has gone to Chicago to visit her mother. But if Claudia is in Chicago, how is it that two FBI agents show up at Linus' office and inform him that Claudia has been killed in a plane crash on her way from New York to Brazil? And why did a man named Jeffrey Holden, the vice president of a major pharmaceutical company, buy her ticket and die beside her?

Enlisting the aid of two fellow conspiracy theorists, Linus heads across the country in search of answers. But as their journey progresses, it becomes frighteningly clear they've left the realm of the academic and are tangled up in a dangerous, multilayered cover-up. Finally, deep in the heart of the American desert, stunned by an ominous revelation, Linus sees he has a new mission: to try to stay alive.